## Process 1. Trigger - loss of contact inhibition triggers cells mobilization 2. Mobilization - cells at edge of wound break contact (integrins) to begin migrating 3. Migration - cells move across the wound ditch (in a thin layer) until they reestablish contact inhibition 5. Differentiation - After migration ends, the epithelial layers ([[Skin Basics]]) thicken from the basal layer to stratum corneum 1. Multipotent epithelial progenitors (nonexclusively) live in hair follicle bulges, move up to facilitate differentiation and regrowth^[Gurtner GC, Werner S, Barrandon Y, Longaker MT. Wound repair and regeneration. _Nature_. 2008;453(7193):314-321. doi:[10.1038/nature07039](https://doi.org/10.1038/nature07039)] > Surgical wisdom: Placement of interrupted subcuticular sutures at the mid-dermis may allow in-folding of the top epithialial layers, slowing epithelialization of the edge, allowing for more time for epithialization evenly across the basal layer, and reducing scars formation (according to John Siebert) #basicscience #technique